P2.3 Haemophilus influenzae immunisation

A Cochrane review/meta-analysis of six placebo-controlled RCTs evaluating 557 patients, conducted to test the efficacy of enteric-coated, killed preparations of H. influenzae in populations prone to recurrent exacerbations of chronic bronchitis or COPD, concluded that there was a small, non-significant 2.048% decrease in exacerbations in the vaccinated group when compared to the placebo group (risk ratio (RR) 0.97, 95% confidence interval (CI) 0.84 to 1.12, p=0.68) (Teo 2014) [evidence level I].