Appendix 1

Use and doses of long-term inhaled bronchodilator and corticosteroids determined in response trials

Response Drug Dose (mcg)              Frequency Delivery
Improved airway function
Improved exercise capacity
Reduced breathlessness
Improved quality of life
Salbutamol 100-200mcg 4-6-hourly MDI/spacer
Salbutamol 200-400mcg 4-6-hourly DPI
Terbutaline 500-1500mcg 6-8-hourly DPI
Salmeterol 50mcg 12-hourly MDI/DPI
Formoterol 12mcg 12-hourly MDI/DPI
Indacaterol 150-300mcg 24-hourly DPI

Anticholinergic (Antimuscarinic)

Ipratropium 42-84mcg 6-8-hourly MDI/spacer
Tiotropium 18mcg 24-hourly DPI
Tiotropium 2.5mcg 24-hourly Respimat
Glycopyrronium 50mcg 24-hourly DPI
Corticosteroid Inhaled
(small particle)
50-200mcg/day 12-hourly MDI/spacer
Budesonide 400mcg 12-hourly DPI
Fluticasone propionate 250-500mcg/day 12-hourly MDI/DPI
Fluticasone furoate 100mcg/day 12-hourly DPI
Ciclesonide 80-320mcg/day 24-hourly MDI – spacer not recommended
MDI=metered dose inhaler. DPI=dry powder inhaler.