…to usual care, the intervention showed no effect on the co-primary outcome of HADS-A (mean difference, 95% CI, -0.60, -1.40 to 0.21) or HADS-D (mean difference -0.66, 95% CI -1.39…
…severe COPD. These strategies include early mobilisation and, where appropriate, minimising medications leading to respiratory depression, regional anaesthesia and controlled oxygen delivery in the post-operative period (Diaz-Fuentes 2016, Lakshminarasimhachar 2016)….
…treatable disease with some significant extrapulmonary effects that may contribute to the severity in individual patients. Its pulmonary component is characterised by airflow limitation which is not fully reversible. The…
…guideline-based indications such as systolic heart failure (Lipworth 2016) [evidence level III-2]. Australian data from a COPD cohort hospitalised for a COPD exacerbation also reflects this (Neef 2016) [evidence level…
…Trial Research 2016). Subsequently, inclusion criteria were altered to include those who desaturated with exertion but were minimally hypoxaemic at rest (SpO2 ≥ 94% resting but desaturating to <90% for…
…Co-existing depression is common with depression reported in 44% of hospitalised patients with COPD (Jimenez-Ruiz 2015). Despite this there is evidence that smoking cessation interventions can be effective. The 2016…
…or personalised medicine in COPD and asthma (Agusti 2017, Agusti 2016, McDonald 2019a). Patients are first assessed through a detailed clinical history and identification of airway disease risk factors (e.g….
…95% CI 3.22 to 11.7) than for control, but long-term mortality favoured LVRS (OR 0.76, 95% CI 0.61 to 0.95) [evidence level I]. 96% of the patients contributing to the…
…the risk of moderate or severe COPD exacerbation compared to LABA/LAMA combination therapy (relative effect 0.70, 95% CrI 0.53–0.94) and single long-acting bronchodilator therapy (relative effect 0.62, 95% CrI 0.48–0.80)…
…mortality (four studies, RR=0.58, 95% CI 0.35 to 0.98) after the end of treatment. There was no effect of early supervised pulmonary rehabilitation on mortality over the longer-term, most likely…