Appendix 5
Table of Minimum Clinically Important Differences (MCID) (Cazzola 2015b)
Health status measures
Patient Reported Outcome Measure (PROM) | Purpose | Domains | No. items | Reliability | Validity | MCID |
---|---|---|---|---|---|---|
St George’s Respiratory Questionnaire (SGRQ) | Assess health status impairment in airways disease(COPD, Asthma, Bronchiectasis) | Symptoms, activity, impacts | 50 | ✔ | ✔ | 4 units |
St George’s Respiratory Questionnaire COPD (SGRQ-C) | Assess health status in COPD – weakest items removed | Symptoms, activity, impacts | 40 | ✔ | ✔ | 4 units |
Chronic Respiratory Questionnaire (CRQ) (short form also available) | Health-related quality of life in chronic respiratory disease | Mastery, fatigue, emotional function and dyspnoea | 20 | ✔ | ✔ | 0.5 units |
Clinical COPD Questionnaire (CCQ) | Health status assessment in a primary care setting | Symptoms, functional state, mental state | 10 | ✔ | ✔ | 0.4 units |
COPD Assessment Test (CAT) | Quantifies symptom burden of COPD, health status measurement | Energy, Sleep, confidence, activities, breathlessness, chest tightness, phlegm, cough | 8 | ✔ | ✔ | 2 units |
Symptom measures
Patient Reported Outcome Measure (PROM) | Purpose | Domains | No. items | Reliability | Validity | MCID |
---|---|---|---|---|---|---|
Modified Medical Research Council (MMRC) | Disability from COPD related to breathlessness | Uni-dimensional | 1 - 5 point scale | ✔ | ✔ | ~ 1, but limited data |
Baseline Dyspnoea Index (BDI) Transitional Dyspnea Index (TDI) | Measurement of dyspnea based on activities of daily living | BDI: functional impairment, magnitude of task, magnitude of effort | BDI 3 TDI 3 | ✔ | ✔ | 1 unit in TDI |
The Breathlessness Cough and Sputum Scale (BCSS) | Tracks severity of resp symptoms and evaluate efficacy in clinical trials - COPD | Breathlessness, cough, sputum | 3 | Acceptable | Acceptable | >1 substantial .6 mod .3 small |
Dyspnoea 12 | Current level of breathlessness severity | Uni-dimensional | 12 | ✔ | ✔ | Not yet established |
Exacerbations
Patient Reported Outcome Measure (PROM) | Purpose | Domains | No. items | Reliability | Validity | MCID |
---|---|---|---|---|---|---|
The EXAcerbations of Chronic Pulmonary Disease Tool (EXACT®) | Evaluates frequency, severity and duration of an AE COPD (Daily) | Breathlessness, cough and sputum, chest symptoms | 14 | ✔ | ✔ | Not yet established |
Evaluating Respiratory Symptom (E-RS®) | Derivative instrument of the EXACT, designed to address the need for a standardized daily diary to assess respiratory symptoms in patients with stable COPD | Breathlessness, cough and sputum, chest symptoms | 11 | ✔ | ✔ | 3 point Δ(total score) 2 point Δ(breathless-ness) 1 point Δ(cough & sp) 1 point Δ(chest symptoms) |