O3.1 Oral corticosteroids

Some patients with stable COPD show a significant response to oral corticosteroids (on spirometry or func­tional assessment). Therefore, a short course (two weeks) of prednisolone (20–50mg daily) may be tried with appropri­ate monitoring. Short courses of oral corticosteroids (<14 days) do not require tapering. A negative bronchodilator response does not predict a negative steroid response (Global Initiative for Chronic Obstructive Lung Disease 2017Senderovitz 1999). If there is a response to oral steroids, continued treatment with inhaled corticosteroidsis indicated, but these may fail to maintain the response (Senderovitz 1999Vestbo 1999).