Appendix 5

Table of Minimum Clinically Important Differences (MCID)

Health status measures

PROMPurposeDomainsNo. itemsReliabilityValidityMCID
SGRQAssess health status impairment in airways disease(COPD, Asthma, Bronchiectasis) Symptoms, activity, impacts 50 4 units
SGRQ-CAssess health status in COPD – weakest items removed Symptoms, activity, impacts 404 units
CRQ
(short form also available)
HR QOL in chronic respiratory disease Mastery, fatigue, emotional function and dyspnoea 200.5 units
Clinical COPD Questionnaire (CCQ) Health status assessment in a primary care setting Symptoms,
functional state, mental state
100.4 units
CAT Quantifies symptom burden of COPD, health status measurement Energy, Sleep, confidence, activities, breathlessness, chest tightness, phlegm, cough 82 units

Symptom measures

PROMPurposeDomainsNo. itemsReliabilityValidityMCID
MMRC Disability from COPD related to breathlessness Uni-dimensional 1 - 5 point scale ~ 1, but limited data
Baseline and Transitional Dyspnea Indices BDI-TDI Measurement of dyspnea based on ADLs BDI: functional impairment, magnitude of task, magnitude of effort BDI 3
TDI 3
1 unit in TDI
The Breathlessness Cough and Sputum Scale (BCSS) Tracks severity of resp symptoms and evaluate efficacy in clinical trials - COPD Breathlessness, cough, sputum 3AcceptableAcceptable>1 substantial
.6 mod
.3 small
Dyspnoea 12 Current level of breathlessness severity Uni-dimensional 12Not yet established

Exacerbations

PROMPurposeDomainsNo. itemsReliabilityValidityMCID
EXACT-PRO Evaluates frequency, severity and duration of an AE COPD
(Daily)
Breathlessness, cough and sputum, chest symptoms 14Not yet established
EXACT - RS Derivative instrument of the EXACT, designed to address the need for a standardized daily diary to assess respiratory symptoms in patients with stable COPD Breathlessness, cough and sputum, chest symptoms 11 3 point Δ(total score)
2 point Δ(breathless-ness)
1 point Δ(cough & sp)
1 point Δ(chest symptoms)