Appendix 1

Use and doses of long-term inhaled bronchodilator and corticosteroids determined in response trials

Response

Drug

Dose (mcg)             

Frequency

Delivery

Improved airway function
Improved exercise capacity
Reduced breathlessness
Improved quality of life

 

 

 

 

 

 

 

 

 

 

 

 

beta-agonist

Salbutamol

200mcg

4-6-hourly

MDI/spacer

Terbutaline

500mcg

6-8-hourly

DPI

Salmeterol

50mcg

12-hourly

MDI/DPI

Formoterol

12mcg

12-hourly

MDI/DPI

Indacaterol

150-300mcg

24-hourly

DPI

Anticholinergic (Antimuscarinic)

Ipratropium

40-80mcg

6-8-hourly

MDI/spacer

Tiotropium

18mcg

24-hourly

DPI

Corticosteroid

Inhaled

Beclomethasone
(small particle)

400-800mcg/day

 

MDI/spacer

Budesonide

800-1600mcg/day

 

DPI

Fluticasone

500-1000mcg/day

 

MDI/DPI

Ciclesonide

80-320mcg/day

 

MDI – spacer not recommended

MDI=metered dose inhaler. DPI=dry powder inhaler.